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Sunday, September 30, 2012
The genetics of white finger disease
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Public release date: 30-Sep-2012[ | E-mail |
Share ] Contact: Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central
Vibration-induced white finger disease (VWF) is caused by continued use of vibrating hand held machinery (high frequency vibration >50 Hz), and affects tens of thousands of people. New research published in BioMed Central's open access journal Clinical Epigenetics finds that people with a genetic polymorphism (A2191G) in sirtuin1 (SIRT1), a protein involved in the regulation of endothelial NOS (eNOS), are more likely to suffer from vibration-induced white finger disease.
VWF (also known as hand arm vibration syndrome (HAVS)) is a secondary form of Raynaud's disease involving the blood vessels and nerves of arms, fingers and hands. Affected fingers feel stiff and cold and loose sensation for the duration of the attack, which can be very painful. Loss of sensation can make it difficult to carry out manual activities. Initially attacks are triggered by cold temperatures but as the disease progresses attacks can occur at any time.
Little is known about what causes the restriction in blood flow, however researchers from Germany investigated the role of SIRT 1 by looking at polymorphisms (naturally occurring variations in DNA sequence) in people affected by VWF.
SIRT1 regulates activation of other genes by controlling how tightly DNA is wound in the nucleus. Tightly wound DNA cannot be 'read' and consequently cannot be used to make new protein. SIRT1 is known to regulate vasodilation by targeting eNOS, a nitric oxide synthase within the cells lining the inside of blood vessels, which regulates smooth muscle contraction, and hence the diameter of the vessel, and the amount of blood that can flow through it.
Of 113 polymorphisms tested, in the gene coding for SIRT1, only four actually affected the protein, the rest were non-coding or false positives. Of these four, only one was different between people with VWF and unaffected controls. A single nucleotide at position 2191 can either be an A or a G. In the unaffected population 99.7% had the A, but amongst the patients with VWF, almost a third had the G.
Dr Susanne Voelter-Mahlknecht from the University of Tuebingen, who led this study, explained, "While this does not mean that only people with the G version of the gene for SIRT1 will get VWF, it can be used to identify a set of people who would be at risk of VWF if they used vibrating hand held tools. Testing for this variant before starting to work with vibrating machinery could prevent years of pain and disability."
###
Media contact
Dr Hilary Glover
Scientific Press Officer, BioMed Central
Tel: +44 (0) 20 3192 2370
Mob: +44 (0) 778 698 1967
Email: hilary.glover@biomedcentral.com
Notes
1. Sirtuin1 single nucleotide polymorphism (A2191G) is a diagnostic marker for vibration-induced white finger disease Susanne Voelter-Mahlknecht, Bernd Rossbach, Christina Schleithoff, Christian-Lars Dransfeld, Stephan Letzel and Ulrich Mahlknecht Clinical Epigenetics (in press)
Please name the journal in any story you write. If you are writing for the web, please link to the article. All articles are available free of charge, according to BioMed Central's open access policy.
Article citation and URL available on request on the day of publication.
2. Clinical Epigenetics, the official journal of the Clinical Epigenetics Society, is an open access, peer-reviewed journal that encompasses all aspects of epigenetic principles and mechanisms, as well as reports on defects of epigenetic regulation, in relation to human disease, diagnosis and therapy.
3. BioMed Central (http://www.biomedcentral.com/) is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Science+Business Media, a leading global publisher in the STM sector. @BioMedCentral
4. BioMed Central, in conjunction with its journal Epigenetics & Chromatin, is hosting the inaugural conference "Epigenetics & Chromatin: Interactions and processes" at Harvard Medical School in Boston, USA from 11 March 2013. Registration for the conference is now open. If you would like to know more please visit www.epigeneticsandchromatin.com/conf @epigenchromatin #eac2013
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 30-Sep-2012[ | E-mail |
Share ] Contact: Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central
Vibration-induced white finger disease (VWF) is caused by continued use of vibrating hand held machinery (high frequency vibration >50 Hz), and affects tens of thousands of people. New research published in BioMed Central's open access journal Clinical Epigenetics finds that people with a genetic polymorphism (A2191G) in sirtuin1 (SIRT1), a protein involved in the regulation of endothelial NOS (eNOS), are more likely to suffer from vibration-induced white finger disease.
VWF (also known as hand arm vibration syndrome (HAVS)) is a secondary form of Raynaud's disease involving the blood vessels and nerves of arms, fingers and hands. Affected fingers feel stiff and cold and loose sensation for the duration of the attack, which can be very painful. Loss of sensation can make it difficult to carry out manual activities. Initially attacks are triggered by cold temperatures but as the disease progresses attacks can occur at any time.
Little is known about what causes the restriction in blood flow, however researchers from Germany investigated the role of SIRT 1 by looking at polymorphisms (naturally occurring variations in DNA sequence) in people affected by VWF.
SIRT1 regulates activation of other genes by controlling how tightly DNA is wound in the nucleus. Tightly wound DNA cannot be 'read' and consequently cannot be used to make new protein. SIRT1 is known to regulate vasodilation by targeting eNOS, a nitric oxide synthase within the cells lining the inside of blood vessels, which regulates smooth muscle contraction, and hence the diameter of the vessel, and the amount of blood that can flow through it.
Of 113 polymorphisms tested, in the gene coding for SIRT1, only four actually affected the protein, the rest were non-coding or false positives. Of these four, only one was different between people with VWF and unaffected controls. A single nucleotide at position 2191 can either be an A or a G. In the unaffected population 99.7% had the A, but amongst the patients with VWF, almost a third had the G.
Dr Susanne Voelter-Mahlknecht from the University of Tuebingen, who led this study, explained, "While this does not mean that only people with the G version of the gene for SIRT1 will get VWF, it can be used to identify a set of people who would be at risk of VWF if they used vibrating hand held tools. Testing for this variant before starting to work with vibrating machinery could prevent years of pain and disability."
###
Media contact
Dr Hilary Glover
Scientific Press Officer, BioMed Central
Tel: +44 (0) 20 3192 2370
Mob: +44 (0) 778 698 1967
Email: hilary.glover@biomedcentral.com
Notes
1. Sirtuin1 single nucleotide polymorphism (A2191G) is a diagnostic marker for vibration-induced white finger disease Susanne Voelter-Mahlknecht, Bernd Rossbach, Christina Schleithoff, Christian-Lars Dransfeld, Stephan Letzel and Ulrich Mahlknecht Clinical Epigenetics (in press)
Please name the journal in any story you write. If you are writing for the web, please link to the article. All articles are available free of charge, according to BioMed Central's open access policy.
Article citation and URL available on request on the day of publication.
2. Clinical Epigenetics, the official journal of the Clinical Epigenetics Society, is an open access, peer-reviewed journal that encompasses all aspects of epigenetic principles and mechanisms, as well as reports on defects of epigenetic regulation, in relation to human disease, diagnosis and therapy.
3. BioMed Central (http://www.biomedcentral.com/) is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Science+Business Media, a leading global publisher in the STM sector. @BioMedCentral
4. BioMed Central, in conjunction with its journal Epigenetics & Chromatin, is hosting the inaugural conference "Epigenetics & Chromatin: Interactions and processes" at Harvard Medical School in Boston, USA from 11 March 2013. Registration for the conference is now open. If you would like to know more please visit www.epigeneticsandchromatin.com/conf @epigenchromatin #eac2013
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-09/bc-tgo092812.php
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Video: GOP address: Obama "puts government first"
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Saturday, September 29, 2012
More can mean less leptin Alzheimer | Health & Fitness Articles at ...
J. Wesson Ashford, MD, Ph.D. A major goal will be to determine whether treatment with leptin reduced the levels of a protein called tau, which is elevated in the cerebrospinal fluid of Alzheimer patients. Replacement therapy in leptin continued .High levels of the hormone leptin regulation of energy was associated with low rates of disease in a study published in TheJournal of the American Medical Association.
Leptin has been shown to reduce the levels of B-amyloid, the main constituent of the deposits, or plaques, that occur in the brain of people suffering from Alzheimer?s disease.
If our results are confirmed by others, leptin levels in older adults may serve as one of many possible biomarker for healthy aging and the brain, especially, may open new avenues in order to possible preventive and therapeutic interventions, write the researchers. Leptin replacement therapy
But Seshadri said it remains to be seen whether leptin replacement therapy would benefit humans with Alzheimer?s or help protect against disease.
He said the study reinforces the growing awareness that the health problems associated with procedures such as obesity and resistance increase the risk of dementia in old age.
Tau protein is a key that allows the transport along the fibers of the brain, he tells WebMD. If leptin decreases the levels of tau protein in cerebrospinal fluid, which tells us something is happening. So we only need 45 patients to demonstrate an effect.
Over 12 years of follow-up, those with lower levels of leptin were about four times more likely to develop Alzheimer?s than those with the highest levels.
Ashford is with the Center Stanford / VA Aging Clinical Research, Stanford, California
The treatment with leptin has been shown in studies on animals recent to improve the performance of the memory, even after the onset of Alzheimer?s disease, such as dementia.
Discovered in the mid-1990, leptin is produced by fat cells and is considered critical for the regulation and. But there is evidence suggesting a role more and more of the hormone in brain development and memory.
Higher concentrations at the beginning of leptin were associated with lower rates of dementia years later. This association was observed even after adjusting for the impact of quarantine abdominal or belly fat, which was recently identified as a risk factor for Alzheimer?s disease early.
The study initially included 785 elderly participants in the Framingham Heart Study in progress, which began enrolling patients in 1948.
The National Institutes of Health recently awarded nearly $ 3 million for a small pilot study of leptin replacement therapy in patients with Alzheimer?s disease.
?Our skeleton with its bones, joints and muscle connections serves us so well in our daily lives that we hardly pay attention to this great system,? said Dr. Elazar Zelzer Department of Molecular Genetics at the Weizmann Institute. ?While previous research has uncovered the mechanisms that contribute to the development and growth of each component of this complex organ and wonderfully adaptable, specific interactions between bones, muscles and tendons that drive the entire musculoskeletal system are not fully understood.
Our study raises a strong possibility that leptin may actually play a role in various pathological processes that cause Alzheimer?s disease clinic, the researcher Sudha Seshadri, MD, of Boston University School of Medicine, tells WebMD. The measurement of levels of leptin
If confirmed, the researchers say the findings could have important implications in the search for effective therapies to prevent and treat disease.
Source: http://www.exercise24.org/?p=514
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Target's up&up baby & toddler food pouches {Giveaway!}
Ear?lier this sum?mer, I shared with you how much we were lov?ing Target?s up&up dia?pers and now Tar?get is back with another fun promo, per?fect for those of you with lit?tle ones?Baby & Tod?dler food pouches!
Up&Up is an exclu?sive Tar?get ? brand designed to pro?vided con?sumers with high-quality, well-designed prod?ucts at low prices. There are actu?ally over 1,000 prod?ucts to select from span?ning 45 cat?e?gories includ?ing health care, house?hold care, per?sonal care, beauty, and baby care?like the up&up baby food. And, now, tod?dler food pouches.
Do your kids love these food pouch things? Mine absolutely do! Even at age 5 (well beyond a tod?dler), Big Brother still loves them! They don?t get them often, so I think they?re viewed as a spe?cial treat around here. Imag?ine how thrilled they were when a box showed up full of? yummy fruit pouches ready to be eaten! 
They loved them! I like that they?re a healthy treat and super con?ve?nient. So handy for toss?ing in the dia?per bag! And, I?m thrilled to find an option that seems a bit larger than the com?peti?tor brands while also being less expen?sive! That?s a win in my book! For more deals, check out coupons for up&up prod?ucts HERE!
Give?away
One lucky Mom Endeav?ors reader will win a box filled with 15 var?i?ous up&up food pouches. Win?ner picks the stage (i.e. baby, tod?dler,?etc).
To Enter:
Use the Raf?fle?copter form below to sub?mit entries. To enter, click the but?ton that says, ?Do it!?, and then com?plete that spe?cific task. Each time you do this, you get one entry. Then con?tinue on, and do as many (or as few) tasks as you like. ONE LUCKY WINNER gets the prize pack!
a Raf?fle?copter give?away
Dis?clo?sure: This post is spon?sored by Tar?get?in con?junc?tion with the Baby?Cen?ter Blog Net?work. We received tod?dler food pouches for the pur?poses of review. How?ever, all opin?ions and expe?ri?ences are my?own!
Source: http://www.momendeavors.com/2012/09/baby-toddler-food-pouches.html
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Penn Immunologists Find a Molecule That Puts the ... - Health.am
? Immunology ? Sep 28, 2012
We couldn?t live without our immune systems, always tuned to detect and eradicate invading pathogens and particles. But sometimes the immune response goes overboard, triggering autoimmune diseases like lupus, asthma or inflammatory bowel disease.
A new study led by University of Pennsylvania researchers has now identified a crucial signaling molecule involved in counterbalancing the immune system attack.
?The immune response is like driving a car,? said Christopher Hunter, professor and chair in the Department of Pathobiology in Penn?s School of Veterinary Medicine. ?You hit the accelerator and develop this response that?s required to protect you from a pathogen, but, unless you have a brake to guide the response, then you?ll just careen off the road and die because you can?t control the speed of the response.?
The research to characterize this immune system ?brake? was led by Hunter and Aisling O?Hara Hall, a doctoral candidate in the Immunology Graduate Group. Additional Penn collaborators included scientists from the Penn Genome Frontiers Institute?s Department of Biology and the Perelman School of Medicine?s Department of Medicine. Researchers from Merck Research Laboratories, the National Institute of Allergy and Infectious Disease, Harvard Medical School and Janssen Research and Development also contributed to the work, which was published in the journal Immunity.
"Healthy people have these cells - you have them, I have them - that are called Tregs,? or regulatory T cells, Hunter said. ?If you don?t have them you develop spontaneous inflammation and disease.?
Different forms of regulatory T cells operate as the brakes on various kinds of inflammation, but, until now, scientists hadn?t been certain of how these Tregs became specialized to do their particular jobs.
Hall, Hunter and colleagues decided to follow up on a molecule called IL-27. Scientists used to think IL-27 played a role in causing inflammation, but, in 2005, a team of Penn researchers, including Hunter, found the opposite; it was actually involved in suppressing inflammation. Thus, when mice that lack IL-27 are challenged with the parasite Toxoplasma gondii, they develop overwhelming inflammation.
?We never worked out how it did that, but it was a paradigm change at the time,? Hunter said.
In the new study, the researchers delved deeper into IL-27?s role. They found that exposing regulatory T cells to IL-27 promoted their ability to suppress a particular type of inflammation. The Penn-led team also demonstrated that they could rescue infected IL-27-deficient mice by giving them a transfusion of regulatory T cells. This finding suggests that IL-27 is required to produce the Treg cells that normally keep inflammatory responses in check during infection.
?Very surprisingly, we were able to show that the Tregs could ameliorate the pathology in this system,? Hall said. ?We don?t think this is the only mechanism by which IL-27 limits immune pathology, but it sheds light on one mechanism by which it could be functioning.?
Further experiments showed that Tregs express a different suite of genes in the presence of IL-27 as compared to another molecule that has been implicated in this process, interferon gamma, or IFN-?. The researchers? findings indicate that the two molecules have division of labor when it comes to suppressing inflammation: IL-27 seems to be important in helping control inflammation at the site of inflammation, whereas IFN-? appears more significant in the peripheral tissues.
?At the site of inflammation, where you?re getting your pathology, that?s where IL- 27 is important,? Hall said.
With a new understanding of how IL-27 may cause a class of Tregs to become specialized inflammation fighters, researchers have a new target for ameliorating the unwanted inflammation associated with all kinds of autoimmune conditions.
?Now we have a molecular signature that may be relevant in inflammatory bowel disease, in multiple sclerosis, in colitis and Crohn?s disease, in rheumatoid arthritis, in lupus,? Hunter said.
Next on tap, the team plans to study IL-27 in the context of asthma, lupus and arthritis.
In addition to Hall and Hunter, the authors included Beena John, Claudia Gonza?lez Lombana, Gretchen Harms Pritchard, Jonathan S. Silver, Jason S. Stumhofer, Tajie H. Harris, Elia D. Tait Wojno, Sagie Wagage and Philip Scott of Penn Vet?s Department of Pathobiology; Daniel P. Beiting, David S. Roos and Sara Cheery of the Penn Genome Frontiers Institute Department of Biology; Steven Reiner, formerly of the Penn Department of Medicine; Cristina M. Tato and Daniel Cua of Merck Research Laboratories; Yasmine Belkaid, Guillaume Oldenhove, Nicolas Bouladoux and John Grainger of the National Institute of Allergy and Infectious Disease; Laurence A. Turka of Harvard Medical School; and M. Merle Elloso of Janssen Research and Development.
The study was supported by the Commonwealth of Pennsylvania and the National Institutes of Health.
###
University of Pennsylvania
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Source: http://www.health.am/ab/more/puts-the-brakes-on-inflammation/
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Friday, September 28, 2012
UBS wins dismissal of shareholder lawsuit
DEAR ABBY: My husband and I just got some shocking news. His father -- age 81 -- is leaving his wife of 60 years! Mom is not entirely self-sufficient and seems dependent on him.Dad found himself a younger woman -- a "chick" of 70. He has announced that he still has sexual needs and wants to enjoy the rest of his life. My husband thinks it will be a short-term fling and he'll return to Mom, but she says she won't be taking him back. (Who knows how she'll feel later?)My problem is, no matter what happens between them, I'm having a hard time even considering forgiving him for his selfishness. ...
Source: http://news.yahoo.com/ubs-wins-dismissal-shareholder-lawsuit-185158905--finance.html
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AMD Trinity desktop chips due next week, promise Core i5-matching power at Core i3 price
Being the industry underdog means you're always in need of a punchy pitch. Fortunately, AMD's latest briefing to journalists in London yesterday contained exactly that: for something like the cost of an Intel Core i3 you'll be able to pick up an overclockable Trinity A10-5800K which, we're told, belongs in the same weight class as a Core i5 with HD 4000 graphics. Exact pricing won't be revealed until the full stack of A10, A8, A6 and A4 processors hits shelves next week, but the top-end A10 will likely cost around $130, based on recent leaks and a glance at what Newegg currently charges for an i3. Unluckily, however, whereas Ivy Bridge was compatible with some previous-generation motherboards, Trinity will require the purchase of a new Socket FM2 motherboard.
The claim of performance parity with the Core i5 just cries out to be tested, but we'll have to wait until early October before we can round up verdicts from full reviews on specialist sites. In the meantime, check out the More Coverage links below for some early previews. Also, if you require something more directly head-to-head with an Intel chip, then that's exactly what you'll find in the video after the break, albeit under AMD's auspices and solely in relation to a single game, Sleeping Dogs. As you'll see, there's nothing to turn hardcore gamers against discrete graphics cards, and there are no clues about non-gaming performance (which is arguably more relevant on an APU-powered system). But the A10-5800K does offer plenty of scope for escapism on a low-power HTPC or all-in-one. Indeed, the more expensive Core i5 is left for dust, not least because it's locked -- unlike AMD, Intel charges a premium for its overclockable K-denoted chips. We'll add further preview links as they become available.
Update: Just added HotHardware's preview, which suggests that the A10 really does game as well as our video suggests in addition to providing a mostly fluid computing experience. As mentioned, however, it's impossible to reach a final verdict until AMD allows sites to publish full benchmarks next week.
AMD Trinity desktop chips due next week, promise Core i5-matching power at Core i3 price originally appeared on Engadget on Thu, 27 Sep 2012 00:01:00 EDT. Please see our terms for use of feeds.
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Video: More on September 26: Get real
British Airways tests eliminating online check-in
It?s a familiar process to most air travelers by now: Watch the clock before your trip and log on to a computer within 24 hours of your flight to check in online. But even that simple routine, which has been a huge improvement over the previous tradition of standing in a long queue at the airport, might go away in the future ? something industry watchers say isn?t necessarily a plus.
Source: http://www.msnbc.msn.com/id/3036697/vp/49185843#49185843
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Thursday, September 27, 2012
Wednesday, September 26, 2012
Using Web Analytics for PPC Optimization - Search Engine Watch ...
If you know anything at all about PPC, you know that campaign optimization is one of the most important tasks a PPC manager can perform. Managers spend most of their day tweaking bids, ad copy, campaign settings, networks, keywords, negative keywords, and many other data points within the PPC engines.
Campaign optimization is absolutely essential to PPC success. But if you?re spending all your time in the AdWords and Bing Ads interfaces, you?re missing a big part of the PPC optimization picture.
The Rest of the PPC Story
PPC metrics like CTR, conversion rate, cost per conversion, CPC, etc. are crucial elements that can?t be ignored. This data tells us what is happening with an account: how much traffic it?s generating, how many sales or leads it?s driving, and how much all of that cost. We get a great picture of what is happening.
The problem is, often we don?t know why.
That?s where web analytics come in. Web analytics tell us what PPC visitors did once they arrived at the website.
?Now wait a minute!? you might be thinking. ?I?m using AdWords conversion tracking, so I can see conversions! Don?t those happen on the website??
The answer is absolutely yes. And if you?re not tracking conversions via either the free PPC engine tracking scripts or a third-party tool, then shame on you.
But does that data tell you why someone converted? How many visits to the site did it take for that conversion to happen? What other pages did they view? Were they already a customer making a repeat purchase, or was this their first visit?
PPC conversion tracking can?t answer those questions. But web analytics can.
Key Analytics Measures for PPC
Even the most rudimentary web analytics measures can tell us something about our PPC campaigns. The following metrics can be found in any web analytics program. I?ll focus on Google Analytics, because it?s so ubiquitous ? but you certainly don?t have to be using Google Analytics to get these numbers.
Bounce Rate
Bounce rate is the percentage of site visitors who visited one page and then left the site.
Usually, a high bounce rate is considered a bad thing. If you?re an ecommerce site, and 80 percent of your PPC visitors are bouncing, that?s not good ? it means that only 20 percent of people are bothering to go beyond the landing page.
But what if you?re using PPC to generate leads, and you have a lead form right on the page? Visitors could conceivably fill out the form and convert right there, without going to another page. In this case, it?s a low bounce rate that?s bad ? it means no one is converting!
As you look at bounce rate, think about your campaign goals, and what the numbers mean.
Average Time on Site
Average time on site measures how long visitors spend on your website, in minutes.
It probably takes at least 4-5 minutes to complete an online order on an ecommerce site, so if you?re an ecommerce PPC advertiser, a longer time on site is good.
What about the one-page lead form, though? Best practices for online lead forms indicate that shorter forms are best. If it takes 4-5 minutes to fill out your form, you?re using the wrong form. In this case, shorter times on site are a good thing!
Number of Pages Visited
This metric is exactly what it sounds like: the average number of pages visited on your site.
Most ecommerce shopping carts are at least 4-5 pages. Add 1-2 pages for your landing page and any additional items the visitor might be interested in, and you?re looking at a good average of 5-7 pages per visit at a minimum.
I bet you know what I?m going to say here. For the one-page lead form, if your average number of pages visited is 5-7, you?ve probably lost the lead. An average of 1.5 is probably good in this case.
Are you seeing a pattern here? In order to accurately evaluate the meaning of web analytics metrics, it?s crucial to think about your PPC campaign goals. Good ecommerce metrics will be very different from good lead generation metrics.
2 Final Caveats
As with all aggregated data sets, web analytics represent averages. And as we all know, averages lie.
While spending a lot of time analyzing what one or two visitors to your site did probably isn't efficient, it does pay to break your data out into segments. For now, just remember that averages may not tell the whole story.
On the flip side, watch out for outliers. Let?s say that your ecommerce campaigns have an average time on site of 7 minutes, but you have one campaign with an average time on site of 22 minutes. While on the surface that might sound good, it?s probably not ? in all likelihood, it means your poor site visitors are trying in vain to find something and aren?t succeeding. So if your underperforming campaign has outlier metrics like this, it?s probably time to optimize your conversion path a bit.
Now go take a look at your bounce rate, average time on site, and number of pages visited. You might be surprised at what you learn!
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Source: http://searchenginewatch.com/article/2207736/Using-Web-Analytics-for-PPC-Optimization
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Tuesday, September 25, 2012
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Kid Friendly Halloween Party Ideas | Inspired By Family Magazine
The first time we took our son?trick or treating he was petrified. The neighborhood we lived in, went all out with their gory Halloween decor and I think he was scarred for life.? Since that experience we decided to start a tradition in our family, to host?a Halloween/Harvest Party?in our home for our friends.
In the past I have tried to get creative in my decorating and crafts, by coming up with some kid friendly Halloween fun ideas?and staying away from?bloody body parts and other scary things. These are some of the?kid friendly?Halloween party ideas I have?come up with and?the others are from BHG.? Check out all the great fun and cute printables!
Last year, I went with the purple, orange and black theme?and the year before it was a Pumpkin Patch theme lots of pumpkin and hay, shown below.? I am still not sure what this years will look like.
images via BHG
KID CRAFTS:
We had a large group so we did some prep work ahead of time to get our pumpkin spiders ready for our guest. Use a melon baller and?make a?hole?in the middle big enough for a tea candle. Glue?googly eyes to the pumpkin and ahead of time make 4 small?holes on the bottom to insert pipe cleaners for the legs.
FOOD:
Candy Corn printable labels link is below. Apple wedges sandwiched with caramel and marshmallows for teeth
Store bought Orange Punch and with a sharpie made pumpkin faces. You can also download this printable for the cute owl soda drinks.? See link below.
Worm Juice- Gummy worms on the edges of?the punch bowl. I taped eyes to the outside of the bowl.
lollipops covered in orange tissue paper and pumpkin faces drawn on. Lollipop spiders printables link is below.
Hotdogs wrapped in frozen biscuit dough or dinner roll, crescent rolls also works and then bake. I used food writing pens to make the eyes.
healthy snack- mandarin pumpkins
Pumpkin cupcakes using chocolate chips for the face and green fondant for the stem.
ACTIVITIES
Photo Booth Dress up
Hang a picture frame from the ceiling and add lots of props for fun pictures
Decorate your pumpkin station- We had markers, feathers, tissue paper, pipe cleaners and paint out on the table for kids to do whatever they wished with their pumpkins
Caramel Apple Biting Contest- Hang apples from ceiling or tree and have kids try to bite the caramel apple without using their hands. It?s quite entertaining to watch!
If you go to BHG here they have a list of all the free printables I mentioned above plus more for you to choose from. All professional images shown above are from BHG.Like this:
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Source: http://inspiredbyfamilymag.com/2012/09/24/kid-friendly-halloween-party-ideas/
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Lost That Loving Feeling? | Couples in Recovery
Simply put: you should be concerned if you are concerned?
The couples who reach a point of dissatisfaction with their romantic relationship that they find themselves considering the need for professional help, or selecting self-help titles such as ?Awakening To Your Soul Mate: A decision to be IN Love ?? have probably known for some time that something is wrong.
It?s generally safe to assume that something is amiss in your romantic relationship if your thoughts, feelings, and desires leave your longing for a real romantic connection.? For the couples that?ve lost the loving feeling, you can read it in their journal writings.
Mary?s Journal Entry:
??????????? ?I am lost.? I don?t know what happened to the closeness that Harry and I used to enjoy.? Could it be that we were young and immature and easily impressed by the excitement that came so spontaneously in our marriage?? Perhaps the kids have preoccupied too much of our time, love, and attention.? I miss my partner and long to see the excitement in his eyes when I walk into a room.? Nowadays, he seems disinterested in me. He ?politely? tolerates my questions about his work and social activities, but my interest in his life does not appear important to him anymore.? What is going on???
Journal entries of this type are common for romantic partners that have become aware, like Mary has, that something is missing in the relationship.? The alarm that is raised in them by what they?ve written may stimulate efforts to renew the bond, or renew the excitement, by planning a trip or scheduling a date night.
The same couple is likely to find that date night commitments all too frequently loose their fervor, and the memories of the romantic vacation have faded within a month of their return to the reality of career, home, and family.? They return to the demands of parenting or career challenges and find themselves once again on the treadmill of life.? Something causes one or the other of them to drift off in private thoughts.
A peak into Harry?s solitary thoughts finds him scheming about a new romance, and his reaction is one of terror.? Let?s do a little eavesdropping.
Harry?s private thoughts:
??????????? ?I need to get a grip of things.? My marriage is dull, boring, and an awful lot of work for very little return.? I don?t find Mary as attractive as I once did and my eyes are frequently wandering around looking for a younger and more mysterious woman to exchange a moment of innocent fanciful intrigue with.? I do not believe that I will ever have an affair ? I love Mary ? but life with her is not exciting and our relationship makes me feel old and undesirable.? I know I am not the young man I once was but this marriage is beginning to feel more and more like a prison than the romantic getaway.? I want and deserve to feel differently.
?Sally (a workplace project partner) makes me laugh and finds my insights amazing.? I feel more valuable to her than I do my own wife.? What is wrong with me? Maybe nothing!? There is nothing wrong with wanting to feel important and desirable.? Besides, the relationship is harmless, she knows I am happily married ? I tell her all the time.? Nothing is every going to come of our attraction to each other, but why does her interest in me matter so much and why do I so thoroughly look forward to our time together??
Harry?s private thoughts are alarming to him but he?s been building quite an extensive system of rationalization and will eventually minimize his concern and silent the alarm until the wanderlust for romantic fantasy is satisfied or worse ? surfaces again with greater force.
Harry, like many partners in a struggling romance, is unhappy and looking for personal fulfillment and excitement. He may be finding it in what has come to be known as a ?work wife.?? There may be nothing sexual or overtly romantic that happens between work spouses for sometime ? or ever, but the risk of infidelity looms large for the partners that look for emotional mates at work or in their community service work.? If the work marriage does not result in a betrayal, there is still great potential for harm.? If meaningful communication and emotional intimacy is so very easy to accomplish with a colleague or social contact, then why work so hard on opening up to one?s spouse?
For many couples like Mary and Harry, the thought of betraying each other is frightening enough to cause one of them to begin reading books on relationships or searching the internet for couples counseling.? Some partners deal with the fear by driving the desire for a new romance into the deeper recesses of their being, along with the lack of fulfillment that they feel in their current relationship, and they just get busy with other things in life.
There are still others who are engaging in what they believe to be harmless flirtations. They will miss all the signs that indicate they are having an emotional affair by rationalizing that there is no harm in having intimate relationships with people other than one?s spouse or partner.? Or they decide that there can be no harm in having an emotionally intimate relationship with someone other than your romantic partner as long as you and your partner have an intimate bond that is mutually satisfying.
It?s not likely that a romantic or sexual affair is born out of a magical moment when two lonely throbbing hearts meet across a crowed room.? It may work that way in the movies, but in real life affairs are likely to occur after a sort of unspoken courtship period in which the prospective partners decide, supposedly by accident, to take their secret attraction to the next level.
The next snapshot reveals the progressive nature of the dissatisfaction and emptiness that can develop in a romance despite our efforts to avoid the truth.
Donna?s morning prayer:
??????????? ?Thank you God for the opportunity to wake up sober for yet another day.? I am so very grateful for all that I have been blessed with in recovery that I feel somewhat ashamed of myself that I am resentful that I have lost my friend and husband to his isolation and depression.? It has been so long since we were able to talk in an intimate way about subjects other than the children or the needs of our extended family members.? I feel so alone. I want what Doug and I had a couple of years ago;? I want to be safe and to be able to lean on each other for support and rely on each other as an accountability partner.? Please bring back the relationship and bond we once shared.?
People like Donna who struggle with permission to acknowledge the loss that they feel when they are emotionally distant from a romantic partner are likely to keep denying their needs until a betrayal occurs or a romance dies.
Some will be fearful of saying the words ?my spouse and I are in trouble? because they are worried that the acknowledgment of romantic problems will be admitting failure.? Other people will be bombarded by negative self-talk when they try to bring their concerns up to others because they will feel ashamed of being dissatisfied with their marriage when they have so many other blessings to be grateful for in recovery.
Now, let us turn up the volume so you can hear the conversation she has with herself shortly after completing the prayer above when the ?critical committee? inside Donna?s head challenges her for daring to speak the painful truth.
Donna?s self-talk:
??????????? ?What is the matter with you? You are so ungrateful!? Doug is a good man. Anyone that you know would be thrilled to have him as a spouse.? He works around the house as a full partner and is not concerned with doing what your friend?s husband?s call woman?s work.? Doug provides well for you and loves and cares for his kids in a way you only imagined a family behaving when you were a kid.? He is home every night, does not gamble and does not drink; and you would never ? ever have to be concerned about him being unfaithful.
?What is your problem? Are you not going to be satisfied until you drive him into the arms of another woman?? So he is not open and vulnerable with you and does not know the first thing about emotional intimacy.? So what!? You knew that going to the altar.? It was you that thought you were going to change him.? He did not mislead you.? YOU MADE YOUR BED, NOW LAY IN IT.?
Donna is repeatedly reassuring herself that she is not only wrong for feeling romantically unsatisfied, but she has only herself to blame for her situation evolving the way it has. Still, others will block out the unhappiness and concern with anger or denial of the need for a more emotionally intimate romantic relationship.? Regardless of your approach, it?s safe to say that there?s a real problem if you find yourself praying about it.
It?s wise to respond to the concerns that you or others raise about your romance, regardless of the way in which those concerns come into your awareness.? Try and refrain from comparing your relationship to those you see around you. ?Try also to refrain from comparing your relationship to memories of past relationships that you have experienced or observed.
Feel free to compare your relationship to the way that you would like it to be.
It?s all right to have great expectations for your relationship with your romantic partner.? Those who might claim that your discomfort is coming from your unreasonable expectations and are quick to tell you that you want too much from your romance are probably in a relationship that you?d find unattractive, or have spent years in their own unfulfilling relationship. Do not settle for less than honesty, openness, mutual support, respectful and loving treatment, intimate communication, being able to count on your partner ? if these are in fact the attributes you are looking for in your relationship.
Simply put, you should be concerned if you are concerned.? You should certainly be concerned if you?ve lost that loving feeling.
?
This article was written by John & Elaine Leadem, senior supervisors of the Leadem Counseling & Consulting offices in Toms River, NJ and East Brunswick, NJ. The content of this article is based on their soon to be published couples book from Leadem Counseling titled: Awakening To Your Soul Mate: A decision to be IN Love (Leadem & Leadem, 2013)
John and Elaine Leadem are licensed clinical social workers whose combined investment in the field of addiction treatment spans more than sixty years. Their commitment to helping recovering families has provided the core inspiration for the development of a "Shared Program of Recovery"? which has helped many couples move from the traditional parallel model of recovery to strong united core support group. They are both certified Sex Addiction Therapist and have co-developed a model for treating couples during the crisis stage of recovery. In addition to being the co-directors of Leadem Counseling & Consulting Services, Elaine and John are seasoned therapeutic retreat leaders in working with recovering couples. As a team they have thus far co-authored three books: In addition, John and Elaine are in the final stages of publishing their latest three masterpieces: Raising the Bottoms: A guide to training professional interventionists, An Ounce of Prevention: A Course in Relapse Prevention, A Shared Program of Recovery: A therapist guide to treating couples recovering from addiction.Like this author?
Catch up on other posts by John and Elaine Leadem (or subscribe to their feed).
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APA Reference
Leadem, J. (2012). Lost That Loving Feeling?. Psych Central. Retrieved on September 25, 2012, from http://blogs.psychcentral.com/couples/2012/09/lost-that-loving-feeling/
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Source: http://blogs.psychcentral.com/couples/2012/09/lost-that-loving-feeling/
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Monday, September 24, 2012
Credit Suisse trims Dubai investment banking,ships jobs to Qatar
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How Brandt Snedeker took the $10 million FedEx Cup bonus
Brandt Snedeker won his second PGA title of the year at East Lake Sunday. Brandt Snedeker collected $1.44 million for the Tour Championship. and the $10 million bonus for capturing the FedEx Cup. Rory McIlroy and Tiger Woods faded early and were never a factor.
Brandt Snedeker reacts after winning the Tour Championship and the FedExCup on the 18th green during the final round of PGA golf tournament at the East Lake Golf Club in Atlanta, Georgia, September 23, 2012.
REUTERS/Tami Chappell
EnlargeBrandt Snedeker played the biggest round of his career for the biggest payoff in golf.
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Needing to win the Tour Championship on Sunday to beat out Rory McIlroy for the FedEx Cup, Snedeker came up with three big birdies on the back nine at East Lake to take all the drama out the final day that had been loaded with possibilities.
Snedeker hit his final tee shot into the grandstand left the 18th green and made bogey. By then, it didn't matter. So dominant was his performance that he was the only player from the last five groups who managed to break par, closing with a 2-under 68.
Along the way, he answered any questions about why Davis Love III made him a captain's pick for the Ryder Cup next week at Medinah.
RELATED: Eight revelations about Tiger Woods by Hank Haney
Snedeker won by three shots over Justin Rose (71) in the Tour Championship, his second title of the year, and collected $1.44 million. And he won the $10 million bonus for capturing the FedEx Cup, which comes with a five-year exemption on the PGA Tour.
McIlroy and Tiger Woods, both of whom could have won the FedEx Cup with a victory Sunday, faded early and were never a factor.
Snedeker joins Woods (twice), Vijay Singh, Jim Furyk and Bill Haas as winners of the FedEx Cup in its six-year history.
McIlroy had won the last two playoff events and three of his last four tournaments dating to his eight-shot win in the PGA Championship. He still is virtually a lock to be voted PGA Tour player of the year, but he had to settle for second place in the FedEx Cup.
"I knew what I needed to do," McIlroy said. "I needed to win. Brandt knew what he needed to do. And he played fantastic. He really deserved it."
It was an emotional week in so many ways for Snedeker, already a high-strung personality. His father, Larry, flew in to watch final round at East Lake, only the second tournament he has attended since having a liver transplant last year.
Snedeker stopped by a hospital in Atlanta to visit Tucker Anderson, the son of his swing coach who was critically injured in a recent car accident and remains unable to communicate with words.
"I asked him if he thought I was going to beat Rory McIlroy, and he gave me a wink," Snedeker said.
He beat everybody at East Lake in a convincing fashion. After taking a double bogey on the par-3 sixth when he hit his tee shot into the water, Snedeker responded with a 40-foot birdie putt on the eighth, an 18-foot birdie putt on No. 13, and chipping in from short of the 17th green to end all doubt.
"I had complete confidence in what I was doing," Snedeker said.
He finished on 10-under 270 and will move into the top 10 in the world ranking for the first time in his career.
Ryan Moore made the strongest run at Snedeker on the back nine, and with an up-and-down behind the par-5 15th green for back-to-back birdies, he was tied for the lead. Moore never was in the mix for the $10 million bonus, though he could have affected the outcome of the FedEx Cup.
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Local world > Chico World Music Festival is a colorful gift to the community.
We talk a lot about Chico Performances, the public-events arm of Chico State that is responsible for bringing the bulk of the world-class music that makes its way to our little isolated city?Ziggy Marley, Elvis Costello, Ang?lique Kidjo are a few on this year?s schedule. But probably the most fun and energizing event that promoter Dan DeWayne and his crew put on features artists of a much smaller profile?many local, in fact?and is completely free. This past weekend, was the 19th year of the Chico World Music Fest, and the east side of campus was packed with international music, food, crafts and art. Longtime fest-goer Alan Sheckter joined the grooving crowd and captured some of the colorful fun.
Pamela Kather?s Suzuki Youth fiddle students on the Kids Stage, Saturday.
PHOTO BY ALAN SHECKTER
Grooving to Reckoning?s bluegrass version of the Grateful Dead at the Sycamore Stage.
PHOTO BY ALAN SHECKTER
Katia Moraes with her band Sambaguru, keeping the Sycamore Stage crowd on its feet on Saturday with Brazilian dance music.
PHOTO BY ALAN SHECKTER
Longtime Chico musician Jerry Morano provides percussion for the new local acoustic Spanish/Mexican-music outfit, Los Caballitos de la Cancion. Sycamore Stage, Sunday.
PHOTO BY ALAN SHECKTER
West African Highlife Band?s Soji Odukogbe (left) and Baba Ken Okulolo on the Sycamore Stage, Saturday.
PHOTO BY ALAN SHECKTER
Twelve-year-old country singer McKenna Gardner, of the Chico School of Rock, sings and strums a tune on the Kids Stage, Sunday.
PHOTO BY ALAN SHECKTER
LoCura close out the Chico World Music Festival on the Sycamore Stage.
PHOTO BY ALAN SHECKTER
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Source: http://www.newsreview.com/chico/content?oid=7738039
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On Baseball: Athletics? Owner See No There in Oakland
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Source: www.nytimes.com --- Saturday, September 22, 2012
Lew Wolff, the owner of the Oakland Athletics, said his team needed a new stadium in San Jose, Calif., to keep the club above Baseball?s poverty line. ...
Source: http://www.nytimes.com/2012/09/23/sports/baseball/athletics-owner-see-no-there-in-oakland.html
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Sunday, September 23, 2012
GlobalGrind: RT @GGPolitics: President Obama says Michelle can do his job? http://t.co/F2wdJX2P
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Source: http://twitter.com/GlobalGrind/statuses/249551719338491904
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BASEBALL TICKET INVITATIONS Birthday Party - (print your own) Personalized Printable by nowanorris
BASEBALL TICKET INVITATIONS
Fun and adorable printable party invitations!
*Text will be personalized for your event! (Sorry, NO font changes!) You will also be able to email us a photo of your birthday girl/boy to be added to the invite.
Color scheme can also be changed to match your party or perhaps represent the colors of your favorite baseball team!
Please note that this listing is for a personalized, high resolution digital file (jpeg) ONLY! The file size is 4"x6" and can easily be printed at a very low cost (typically 10 or 15 cents a piece) at a photo lab of your choice (i.e. Walmart, KodakGallery, Shutterfly). Of course, there is no reason why you couldn't print these at home on your own printer should you choose.
If you choose to have these "tickets" printed as 4"x6" photos, please note that there will be white borders on both the left and right hand sides. Simply trim away and you will have yourself an impressive, true-to-size ticket invitation that measures approximately 2 1/4" x 6" in size!
You will receive your jpeg file within 24 hours of receiving PayPal payment and your text personalization information/photo. The file will be emailed directly to the email address in which I am provided with via PayPal.
**You may request a PDF file at no extra charge!! The PDF will be set up for printing 4 tickets per page if you are choosing to print these yourself instead of having them done as 4x6 "photos". All you have to do is ask. :)
***We will send you a private message once your purchase has been made with instructions on where to email us your photo and custom text!
Please don't hesitate to message us with any questions you might have.
Matching baseball thank you cards can be purchased here:
https://www.etsy.com/listing/101865744/personalized-birthday-party-baseball
Thanks for looking!
Have any questions? Contact the shop owner.
Source: http://www.etsy.com/listing/95927434/baseball-ticket-invitations-birthday
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