Wednesday, October 31, 2012

iOS gets a new Google Search app, and it holds its own against Android

Google today announced an updated Search app for iOS devices. That in and of itself is should be cause for celebration, but it's the the new voice search that has us particularly excited. (Especially since Siri hasn't quite lived up to expectations.)

So how's Google Search stack up? Set side by side with its Android counterpart, quite well. We gave it a gander from an Android Central point of view and came away pretty impressed. Lacking on iOS is the deep integration with the operating system, but that's to be expected. Have a look at the video after the break and see for yourself.

Google Search



Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/Yn5J7_fTN_Q/story01.htm

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Schools Closed To Students Until Monday; Staff Returns Friday ...

New York City students likely will return to school on Monday, making it at least a full week off of school because of damage and clean-up efforts from superstorm Sandy.

Mayor Michael Bloomberg said at a Wednesday news briefing that school faculty and staff are being asked to report to work on Friday. He acknowledged that the school closures are difficult for families but he said there were dozens of schools damaged in the storm as well as complicated transit and power problems to resolve.

"I know this is a great inconvenience to parents who may be missing work because they don't have anybody to take care of their kids. But the bottom line is there's an awful lot of schools that have received damage or won?t have power and it's just so many that in the end we need the next four or five days to clean up," he said. "Hopefully by Monday everything will be back."

Dolores Troy-Quinn, principal of PS 186 Castlewood in Bellerose, Queens, said even though some students may be enjoying the time at home, it's not good "educationally-speaking."

"You get in a groove, you get in a hum," she said, "and then all of a sudden you're off. And then you have to get back on track."

Quinn added that time away from school can be particularly difficult for special education students. Nearly 30 percent of her student population are children with special needs.

A parent commented on SchoolBook's Facebook page to the same point. She said "lack of structure is horrendous" for students with disabilities.

"My son, who has autism, just doesn't understand what's going on," she said. "Thank goodness we didn't lose power or internet & cable ? otherwise I?d be done for!"

Ronda Matthews, a fifth grade teacher at P.S. 321 in Park Slope, said she is ready to get back to the classroom because she was in the middle of an elections-related lesson with her students.

"I really want to teach, because by the time we get back to work the election will almost be over," she said.

Her husband, Scott Matthews, teaches math at Brooklyn Technical High School and shared the same eagerness to get back to school.

"We have a curriculum that is jam-packed full of stuff and it doesn't help when we miss all these days, he said.

Scott was planning on giving an exam this week, but said he will likely give students a day to review when they return to school.

But while schools are closed, Scott and Ronda said they have been enjoying the family time with their own children, and have been "doing school at home," said Ronda, including reading and doing puzzles.

Elizabeth Ellis, a parent of a second-grader and fourth-grader in Greenwood Heights, said she "personally does not have qualms" about her children being out of the classroom in this situation, because they have been active thinkers at home. She said her children and their neighbors have used their time at home to create an imaginary world.

"It's a club that they created for themselves with a whole language and a whole alphabet," she said.

For her part, Quinn, the Queens principal, said she has been spending these past few days keeping in touch with teachers and parents, catching up on email and reading.

"I'm trying to stay on top of things and stay in education mode," she said.

She and a science teacher at the school also went to P.S. 186 yesterday to feed and check on the school's hamsters and lizards. And when students return to school ? hopefully Monday, according to the mayor ? she knows there will be some review for students on routines and behavior, in addition to academic content.

"We'll talk about the storm," she said. "I'm sure the kids will have a lot to say. And then we'll get back to the business of education."

Source: http://www.wnyc.org/blogs/wnyc-news-blog/2012/oct/31/schools-closed-students-until-monday-staff-returns-friday/

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Nokia says shipping new Lumia smartphones this week

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Top Reasons Why a Limited Liability Corporation Makes Sense for ...

Doctors who are interested in learning how niche medical practices can help them make their business operations more efficient will be interested in discovering the sensibility of a limited liability corporation (LLC). Even physicians who are much better versed in healthcare than they are in the legal aspects of running a business often appreciate the value of operating an LLC, particularly when they have chosen to run a cash pay medical practice. Once you have successfully built your cash pay medical practice, your attention will undoubtedly turn to how to effectively protect your business. Among the many benefits of filing your cash pay medical practice as a limited liability corporation are:

? Less paperwork than a traditional corporation. In the spirit of reducing overall paperwork, many firms that specialize in marketing for physicians will suggest forming a limited liability corporation. Forming a corporation usually means that physicians will need to keep substantial records and maintain meticulous paper records; this administrative headache is largely avoided by filing to have your cash pay medical practice designated as a limited liability corporation. ? Ability to form an LLC with a single owner. Physicians who have chosen to use healthcare marketing tools to establish a cash only practice often run a single-physician office. Many states allow the formation of LLC?s with a single owner, which means that the process is streamlined even further. No hassles with Boards of Directors; and the ability to make decisions yourself-?this is an important benefit of forming an LLC. ? Default tax classification. Utilizing default tax classification, physicians are often able to save money on taxes. Tax liability is assessed at the member level, rather than at the overall LLC level. Some states, however, will levy a -?franchise tax-? from limited liability corporations as compensation for the privilege of limited liability. Having an LLC also means that it combines the limited liability features of a corporation and the flow-through tax treatment of income and losses of a partnership. ? Limited liability. Medical marketing firms will often tout the benefits of limited legal and fiscal liability that comes with a limited liability corporation. Members-?in this case the physician/owner-?are protected from some of the acts and debts of the corporation. Firms that provide healthcare marketing resources can give interested physicians the particulars about legal liability. Unlike a general partnership, owners of an LLC have limited liability and, unlike limited partners in a limited partnership, they do not lose their limited liability if they actively participate in management. ? Free from the rules of an S corporation. While its flow-through tax advantages are generally slightly superior to those of an S corporation, an LLC is not subject to the numerous technical rules that apply to S corporations. Thus, for example, an LLC can have more than 35 shareholders; have foreign owners (-?members-?); have owners that are corporations, partnerships, trusts, or other LLCs; own 80% or more of the stock of an affiliated corporation; derive a large portion of its revenue from certain net passive income sources; and issue more than one class of stock. Violation of any one of these technical restrictions would disqualify an S corporation. To help physicians decide if a cash pay medical practice or a limited liability corporation is a possibility for their situation, Hippocrates Publishing stands available as an excellent medical marketing resource. Since 2004, Hippocrates Publishing has provided informative resources to thousands of medical professionals in countries around the globe. Hippocrates Publishing?s distinctive specialty is writing and publishing books and instructive booklets that guide physicians towards finding success with medical practice marketing and niche medical practices. Visit www.HippocratesPublishing.com or call today at 877-408-2462 for additional information on how to turn your cash pay medical practice into a limited liability corporation.

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Source: http://hotnews.blogspages.com/2012/10/30/top-reasons-why-a-limited-liability-corporation-makes-sense-for-your-cash-pay-medical-practice/

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Video: Conn. governor: ?Rescue efforts under way?



>> malloy is with us right now. governor, good morning to you.

>> good morning.

>> yesterday you used the word catastrophic to describe what would happen with this storm. did it live up to that expectation? how bad is it?

>> it's pretty bad. the fire fighter died in easton is emblematic of that. we have trees down everywhere, poles down everywhere. the amount of flooding damage is unbelievable. we had thousands of people trapped in homes at the height of the storm last night. in fact, i went on tv to tell people to stay in place because we didn't want people to try to be swimming out or walking out through high water or driving out. having said all of that, i think the connecticut folks responded pretty well. most heeded the call. most did the right thing to get out of harm's way. we had a series of fires last night in greenwich and saybrook. we lost a number of houses and housing units to fires, to flooding, to wind damage. obviously there will be a lot more assessment today. we know we have over 635,000 customers without power. we know we have water damage to at least three if not four major sewer treatment facilities that will take some period of time to repair. so we've got a lot of work ahead of us. i want to thank the president. united states who did a magnificent job in fema who had really done some amazing early work to get us ready, but now the hard work will start.

>> and governor, you talked about the evacuations. do you have any sense of how many people may still be stranded this morning? do you have search and rescue efforts under way?

>> we do have search and rescue efforts under way. we have -- we had mobilized 850 troops. they have been deployed throughout the state. we have a number of teams, regional teams, as well as others that are responding. the water's receded for a period of time, though they will start to come back to some extent, much lower than what we saw last night, but, you know, we're going door to door and house to house to make sure people are okay and that if they need our assistance at this point, we're making it available. we had thousands of people in shelters last night, certainly hundreds of thousands of people probably staying with friends or relatives elsewhere in connecticut . i'm very grateful to the people of connecticut to responding. our municipal officials by and large did a magnificent job preparatory to the storm so that handling the storm at its height was more manageable than we might have thought. only because of the hard work that was done.

>> well, a long day and days ahead for you and your team there. connecticut governor dannel malloy , thank you so much.

>> thank you.

Source: http://video.today.msnbc.msn.com/today/49607185/

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Tuesday, October 30, 2012

Syrian regime attacks strategic northern city

BEIRUT (AP) ? Syrian warplanes pounded a strategic northern city with three airstrikes Tuesday as ground troops pushed forward in an intensified effort to recapture the area recently taken by rebels, activists said.

The airstrikes targeted Maaret al-Numan, located on the highway connecting Syria's two main cities, Aleppo and Damascus. It was captured by rebels on Oct. 10 and in the weeks since, the regime has subjected the city and the area around it to heavy air bombardments.

The rebel hold on Maaret al-Numan has disrupted the regime's ability to send supplies and reinforcements to Aleppo, where government forces have been bogged down since July in a bloody fight for control of Syria's largest city. Rebel advances over the past week in Aleppo have added urgency to opening the route.

"The regime wants to recapture Maaret al-Numan because it links Damascus with Aleppo," said Rami Abdul-Rahman, head of the British-based activist group Syrian Observatory for Human Rights. "It is a very strategic city." He said ground troops were fighting rebels on the southern edge of the city, 80 kilometers (50 miles) southwest of Aleppo, and added that reinforcements were being sent to the rebel side in the city from nearby Hama province.

President Bashar Assad's air force unleashed scores of airstrikes around the country on Monday and anti-regime activists said it was the most widespread bombing in a single day since the uprising began 19 months ago. Maaret al-Numan was among the hardest hit places on Monday as well.

The death toll for what was supposed to be a four-day cease-fire ending Monday exceeded 500, and activists speculated that the government's heavy reliance on air power reflected its inability to roll back rebel gains, especially in the north of the country near the border with Turkey's where rebels have control of swathes of territory.

Anti-regime activist say more than 35,000 people have been killed since the uprising started in March 2011.

In Tuesday's air raids on Maaret al-Numan, the Observatory said four people, three of them young girls, were killed.

An amateur video showed the three girls draped in white death shrouds, in compliance with Islamic practice, and two of them had had blood on their faces. The narrator identified two of them as Shahad and Sidra Homsi, as a man wrote their names on their chest. It was not clear whether the two girls were sisters. Next to them, a dead man with a white beard was on the floor and a man, believed to be his son, washed blood from his face with water. The man could be heard saying: "Go to heaven dad. May God take your revenge."

The videos could not be independently verified because of reporting restrictions in Syria, but they appeared genuine and corresponded to other Associated Press reporting on the events depicted.

The Local Coordination Committees, another activist group, put the death toll from the airstrikes and ground fighting at 19. Discrepancies in casualty tolls are frequent because of restrictions on independent reporting and the chaos on the ground.

There were also reports of new violence around the capital Damascus.

State-run Syrian TV said air force Maj. Gen. Abdullah Mahmoud al-Khalidi was assassinated in the restive neighborhood of Rukn Eddine. The TV did now say how or when he was killed although such an attack could be seen as retaliation against air force officers for air raids that have been used increasingly since summer.

The LCC and the Observatory reported air raids on several suburbs of Damascus including the areas of Arbeen, Zamalka and Douma.

Syrian troops and rebels clashed in the Palestinian refugee camp of Yarmouk, activists said. The LCC and the Observatory said the fighting broke out after midnight, but they had no word on casualties. Palestinian refugees in Syria tried to stay on the sidelines when the uprising began. But many Palestinian youths have joined the fight as they became enraged by mounting violence and moved by Arab Spring calls for greater freedoms.

The U.N. envoy to Syria tried to broker a cease-fire to coincide with the four days of the Muslim holiday of Eid al-Adha, which ended on Monday. But the truce never took hold and violence continued apace through the weekend.

In Turkey, Foreign Minister Ahmet Davutoglu expressed "great sadness" that the cease-fire did not hold. He said Turkey, which was once a strong ally of Assad, will not engage in a dialogue with the Syrian government.

"Unfortunately the attacks continued and the Syrian people spent the holidays suffering great pain," Davutoglu told a news conference in Ankara. "There would be no meaning to forging a dialogue with a regime that pressed ahead with such a massacre even during the holidays."

Source: http://news.yahoo.com/syrian-regime-attacks-strategic-northern-city-112454573.html

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TiVo Premiere fall update starts rolling out with more HD menu screens and a few other tweaks

We got an early peek at some of the newly revamped menus from TiVo's fall update a few days ago, and now the company has announced it is officially rolling out to retail Premiere DVRs, with cable-provided boxes getting the update at some point in the future. Those on the priority list are first up so some TiVo Community posters report they've already received it and can confirm the Netflix app is "still terrible." Besides the upgraded screens for Season Pass Manager, To Do List, History and My Shows (beyond the new look, they each have gained a few new features), Parental controls has replaced KidZone settings, there are some new games in the apps menu and users can name their DVR in the menus. Hit the source link to check out the full list of changes,

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TiVo Premiere fall update starts rolling out with more HD menu screens and a few other tweaks originally appeared on Engadget on Tue, 30 Oct 2012 16:11:00 EDT. Please see our terms for use of feeds.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/1oPmOf_bGqE/

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LG Nexus 4 Gallery

Nexus 4

The 4.7-inch Nexus 4 from LG is officially official as of today, packing a Snapdragon S4 Pro processor, 16Gb of storage and 2GB of RAM while running on a fresh version of Jelly Bean - Android 4.2. Check past the break for the image gallery of the LG Nexus 4.

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Source: http://feedproxy.google.com/~r/androidcentral/~3/b9KQWLjd7L8/story01.htm

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Demo Memo: 119 Million Home Improvement Projects

In the past two years, homeowners have undertaken 119 million home improvement projects, according to the 2011 American Housing Survey. They spent $358 billion remodeling rooms, upgrading systems, and replacing interior or exterior features of their house.

Most often homeowners hire professionals to do the job. Nearly two out of three home improvement projects undertaken in the past two years were done by professionals. Homeowners spent $295 billion on these projects--or 82 percent of total home improvement spending. The median cost of a professional project was $3,900, but the cost ranged from $30,000 for a kitchen addition to just $500 for appliance replacement and installation.

Some homeowners are brave enough to do it themselves. Homeowners have tackled 44 million do-it-yourself projects in the past two years, spending a total of $64 million. The median cost of a do-it-yourself project was $950, with the cost ranging from $5,000 for a kitchen renovation or a new garage to just $150 for plumbing work. The data do not reveal how many do-it-yourselfers ended up calling a professional to tidy things up.

Source: Census Bureau, 2011 American Housing Survey

Source: http://demomemo.blogspot.com/2012/10/119-million-home-improvement-projects.html

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Monday, October 29, 2012

Mortgage loan calculette pret immobilier and the Road to Financial ...

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Getting liberty via fiscal debts on and on after your targets directly into purchase your home is not going to end up being as simple as you may think. It?s plausible to calcul pret immobilier that it is squander of cash to pay rent each month when you got the ability to buy along with invest in your own property.

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Re-financing your own Home loan. It should be a typical operating procedure to be able to carry out a mortgage overall health examine every 5yrs. There is a pretty good chance that a more thorough and cheaper home finance loan offer will be on sale. Utilizing re-finance mortgage car loan calculator, you can have an estimate regarding methods a lot it is possible in order to save whenever you re-finance your own mortgage.
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Attempt to negotiate your own mortgage. If you learn it hard to manage the house loan responsibilities, you must proceed speak to your mortgage broker and ask if you?re able to bargain the relation to your home loan. Ask them whether they?d like to provide you with a reduce in interest rate or give you extra time of the house loan term in order to lessen your repayments. Keep in http://calculatrice-enligne.com/calculette-pret-immobilier that your loan provider prefers to work along with you and get their back again rather than allowing you to default.

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Source: http://aayahanolosha.net/archives/4587

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The Importance Of Dentists In Leeds | Health & Fitness

Leeds is the third largest city in the United Kingdom. Hence, it has a large population. Physical health is an obligatory need in such a large city because to attain a society without problems, keeping a good health is essential. Physical health can be divided to many parts. Dental health is one of the most important parts of them. Keeping healthy teeth is important as healthy teeth reveal the healthiness of the entire body. Poor teeth can be an early symptom of serious illnesses like AIDS, diabetes and osteoporosis. You must visit a dentist on a regular basis in order to keep your dental health as well as to avoid serious conditions like diabetes, osteoporosis and coronary disease.

There are so many dentists available in Leeds. Leeds City Dentalcare Services Ltd www.leedscitydentalcare.co.uk/sevices-inman-aligner-clear-braces-leeds.php can help you to maintain healthy teeth by continually checking your teeth. You must attend to a dental clinic frequently even though you don?t feel any discomfort with your teeth. Many oral issues do not have any nasty symptoms like dragon breath. So, sometimes you may not find any issues in your mouth. But, the dentist finds those issues by doing a full check-up and advice you to take further actions. Some dental issues can cure very easily while some other needs deep attention.

When choosing a dentist you should check whether the dentist is adhering to regulations and standards of dental practice Leeds because there are many unethical dentists out there but NOT Leeds City Dental Limited www.leedscitydentalcare.co.uk/services-dental-implants-dentists-leeds.php who tries to cheat you and snatch your money. First of all, you should check whether he or she is an approved dentist or not. An approved dentist should have an own place which is suitable for a dental hospital with vital dental equipment like dental chair, patient education monitors, intra-oral cameras, videos and digital x-rays. The clinic needs to clean and carefully maintain with sterilized instruments. Dental patient should be comfortable visiting and taking medicines from a dental clinic.

Most common dental diseases are bad breath, tooth decay, gum disease, oral cancer, mouth sores, tooth erosion, tooth sensitivity and toothaches. A bad breath may occur because of a bacterial infection or an oral cancer. Tooth decay is known as one of the most common disease in the USA. This disease usually occurs if you don?t keep your mouth clean and brushed every day. Gum disease may be an early symptom of strokes and heart attacks. Oral cancer is known as one of the deadly disease in the world. In United States, at least a one person dies every hour, every day.

Cosmetic dentistry is another type of dentistry which dentists are responsible for. This includes teeth whitening, bonding, tooth reshaping, bite reclamation and many others. Teeth whitening Leeds is very popular among folks. Some people have misty teeth because of many reasons such as excessive fluoride usage, tobacco use and natural reasons like aging, genetics. These dull teeth can be brightened by many teeth whitening options. Dentists in Leeds do this as well. Channeling a dentist frequently can prevent not only dental problems but also serious illnesses like diabetes, oral cancer, heart attacks, strokes and many others. Read more www.leedscitydentalcare.co.uk/services-botox-dermal-fillers-beeston-leeds.php about Leeds City Dentalcare on this link!

Source: http://www.theyellowads.com/health_fitness/the-importance-of-dentists-in-leeds/

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Pampered pooches show off their Halloween style | pooches, event ...

With dogs dressed as spiders, lady bugs and cows, a pet fundraising event in Black Forest Sunday was the perfect chance for dog owners to show off their spoiled and costumed pooches.

?I just couldn?t help getting them dressed up,? Sherry Brand said of her rat terrier mixes Susie and Kimmie, dressed as a hot dog and a bumblebee. Each year they each get a new costume and winter coat, she said.

?People think I?m nuts, but that?s OK,? she said.

Susie, Kimmie and about 30 other dogs spent their Sunday afternoon at the Double D Ranch in Black Forest for the first annual Howl?ween Party organized by the Mutts Welcome Meetup group. The event, which included a costume parade, agility contest and lots of dog treats, was a fundraiser for Colorado Springs Together nonprofit organization.

?We wanted a way to celebrate the season by having fun with our dogs and also have a good cause,? said Kyle Davidson, owner of the Phur Seasons Pet Spa, which also helped sponsor the event.

This wasn?t a professional dog show. Mostly the dogs roamed wild, feeling free to sniff each other or wander through the costume contest when it wasn?t their turn. There were a couple of growls, and more than one pooch tried to shake off his costume.

Joshua and Kristy Oliver saw constant costume malfunctions when their pugs Lucky and Daily refused to wear the hoods to their chicken and pig costumes.

?When they aren?t wearing hoods, they love to be dressed up,? Joshua Oliver said. They usually wear sweaters in the winter and when the weather gets warmer, they switch over to their summer wardrobe, he said.

Summer wardrobe?

??They have sun dresses,? he explained. ?And tank tops.?

The winner of the costume contest was Sam, short for Samantha ?dressed as a cow with a fluffy wagging tail. She?s a 5-year-old Pomeranian who was rescued from a puppy mill, said her owner Sarah Larrabee. She said it took the dog about two years to truly be comfortable around her family and she?s still often shy around others.

Larrabee was excited about the win, but said she normally doesn?t dress the dog up.

?Maybe I will now,? she joked.
?
Contact Maria St. Louis-Sanchez: 636-0274
Twitter @mariastlouis
?Facebook Gazette Maria St. Louis-Sanchez

Source: http://www.gazette.com/articles/pooches-146522-event-costumed.html

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The Not-so-spooky Presidio Pet Cemetery - Hidden Histories ...

Welcome to Curbed's ongoing series titled Hidden History, where Curbed highlights a Bay Area location with a secret past. Maybe it's no longer there, maybe it's been converted into something else, but each spot holds a place in Bay Area history - even if not many people know it. Have a suggestion or know a place with a secret history? The tipline's always open or you can leave a comment after the jump.

Just in time for Halloween, this week's Hidden History focuses on the spooky ghostly world of cemeteries. But not just any ole eternal resting place - the Presidio Pet Cemetery.

The final resting place for hundreds of animals owned by families that were stationed at the Presidio, the pet cemetery dates back to the 1950's. According to the National Park Service, there are no official records for the site, meaning it probably sprung up from the families themselves with authorization from one of the commanding officers. There are legends of previous incarnations of the cemetery, which some believe was originally a burial ground for nineteenth-century cavalry horses or World War II guard dogs.

presidio%20pet%20cemetery%201957%20NPS%20v2.jpgThe sons of Capt. J. K. Moore pay tribute to their collie, Heidi, in 1957 [Photo: NPS]

The grave markers feature some heart-wrenching and historic details on the beloved pets, including their birthplace (like Patches the Cat born in Dachau), family names and owners' ranks, including majors, colonels, and generals. Some look like official military tombstones, due to Presidio Boy Scout volunteers who replaced crumbling markers sometime in the late 1980s or early 90s.

presidio%20pet%20cemetery%20tombstones%20bunky%27s%20pickle.jpgPresidio Pet Cemetery [Photo: Bunky's Pickle]

When the Presidio was in process of becoming a National Park, one (heartless?) congressman against the NPS conversion used the pet cemetery as fodder, sending letters to his supporters with a photo of the pet cemetery and the headline asking "Is This Your Vision of a National Park?" Apparently it was, because the Presidio became part of the Golden Gate National Recreation Area in 1994 (though the cemetery is not included in the official National Historic Landmark district).

presidio%20pet%20cemetery%20telstar%20logistics.jpgPresidio Pet Cemetery during construction of Doyle Drive [Photo: Telstar Logistics]

Today the cemetery is officially closed to new burials, but since it isn't patrolled, people still sneak in to bury their pets. When the Doyle Drive project began a few years ago, the pet cemetery was designated an "environmentally sensitive area," so it was protected from construction.
? Presidio Pet Cemetery [NPS]
? Presidio pet cemetery protected [SF Gate]
? List of Graves by Pet Name [Honan.net]
? Presidio Pet Cemetery Survives Toxic Scare [Found SF]

Source: http://sf.curbed.com/archives/2012/10/29/the_notsospooky_presidio_pet_cemetery.php

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The Reference Frame: Preons probably can't exist

Don Lincoln is the star of several cute Fermilab videos in which he explains various issues in particle physics. He's also authored several related texts for Fermilab Today.

He chose a much more controversial topic, namely preons, for his fresh article in the Scientific American:

The Inner Life of Quarks
Preons are hypothetical particles smaller than leptons and quarks that leptons and quarks are made out of. But can there be such particles?

At first sight, the proposal seems natural and may be described by the word "compositeness". Atoms were not indivisible, as the Greek word indicated, but they had smaller building blocks ? the nucleus and the electron. The nuclei weren't indivisible, either ? they had protons and neutrons inside. The protons and neutrons weren't indivisible ? they have quarks inside.

Why shouldn't this process continue? Why shouldn't there be smaller particles inside quarks? Or inside the electron and other leptons?

Many people who pose this question believe that it is a rhetorical question and they don't expect any answer. Instead, they overwhelm you with detailed speculations about the possible composition of quarks and leptons while they possess lots of wishful thinking when they believe that all the problems they encounter are just details that can be overcome.

(Pati and Salam introduced preons for the first time in 1974. One of the other early enough particular realizations of preons were "rishons" by Harari, Shupe, and a young Seiberg, which means "primary" in Hebrew. I guess that prazdrojs and urquells would be the Czech counterparts. The terminology describing preons has been much more diverse than the actual number of promising ideas coming from this research. The names for "almost the same thing" have included prequarks, subquarks, maons, alphons, quinks, Rishons, tweedles, helons, haplons, Y-particles, and primons.)

However, the question above is a very good, serious question and it actually has an even better answer that explains why.

Mass scales and length scales

Since the mid 1920s and realizations due to Louis de Broglie, Werner Heisenberg, and a few others, we've known about a fundamental relationship between the momentum of a particle and the wavelength of a wave that is secretly associated with it:\[

\lambda = \frac{2\pi \hbar}{p}.

\] You may use units of mature particle physicists in which \(\hbar=1\). In those units, you may omit all factors of \(\hbar\) because they're equal to one and the momentum has the same dimension as the inverse length. Note that adult physicists also tend to set \(c=1\) because the speed of light is such a natural "conversion factor" between distances and times that has been appreciated since Einstein's discovery of special relativity in 1905.

In those \(\hbar=c=1\) units, energy and momentum (and the mass) have the same units, and space and time have the same units, too. The first group is inverse to the second group. Particle physicists love to use \(1\GeV\) for the energy (and therefore also momentum and mass); the inverse \(1\GeV^{-1}\) is therefore a unit for distances and times. One gigaelectronvolt is approximately the rest mass of the proton, slightly larger than the kinetic and potential energies of the quarks inside the proton; the inverse gigaelectronvolt interpreted as a distance is relatively close to the radius of the proton.

At any rate, the de Broglie relationship above says that the greater momentum a particle has, the shorter the wave associated with it is. Similarly, the periodicity of the wave obeys\[

\Delta t = \frac{2\pi\hbar}{E}

\] where \(E\) is the energy. The phase of the wave returns to the original value after a period of time that is inversely proportional to the energy. Now, it is sort of up to you whether \(E\) is the total energy that contains the latent energies \(E=mc^2\) or whether these terms are removed. If you want a fully relativistic description and you're ready to create and annihilate particles, you obviously need to include all the terms such as \(E=mc^2\).

On the other hand, if you study a non-relativistic system, it may be OK to remove \(E=mc^2\) from the total energy and consider \(mv^2/2\) to be the leading kinetic contribution to the energy. That's how we're doing it in non-relativistic quantum mechanics. These two conventions differ by a time-dependent reparameterization of the phase of the wave function (which isn't observable),\[

\psi_\text{relativistic}(\vec x,t) = \psi_\text{non-relativistic}(\vec x,t) \cdot \exp(-i\cdot Mc^2\cdot t/ \hbar)

\] where \(M\) is the total rest mass of all the particles. The relativistic wave function's phase is just rotating around much more quickly than the non-relativistic one.

Preons don't explain any patterns

Fine. Let's return to compositeness and preons. When you conjecture that leptons and quarks have a substructure, you want this idea to lead to exciting consequences. For example, you want to explain why there are many types (flavors) of leptons and quarks out of a more economic basic list of preonic building blocks. It's not a necessary condition for preons to exist but it would be nice and sort of needed for the idea to be attractive.

This goal doesn't really work with preons. Note that it did work with quarks; that's how Gell-Mann discovered or invented quarks. There were many hadrons and the idea that all these particles were composed of quarks was actually able to explain a whole zoo of hadrons ? particles related to the proton and neutron, including these two ? out of a more economic list of types of quarks.

Gell-Mann's success can't really be repeated with the preons. The list of known leptons and quarks is far from "minimal" but it is not sufficiently complicated, either. Quarks have three colors under \(SU(3)_c\). And both leptons and quarks are typically \(SU(2)_W\) doublets. And both leptons and quarks come in three generations.

These are three ways in which there seems to be a "pattern" in the list of types of quarks and leptons; three directions in which the lists of quarks and leptons seem to be "extended". But none of them may be nicely explained by preons. First, you can't really explain why there are \(SU(2)_W\) doublets or \(SU(3)_c\) triplets. Whatever elementary particles you choose, they must ultimately carry some nonzero \(SU(2)_W\) and \(SU(3)_c\) charges ? and the charges of the doublets and triplets are really the minimal ones (the simplest representations) so whatever the preons are, they can't really be simpler than quarks or leptons.

(Here I am assuming that the gauge bosons and gauge fields aren't "composite". The possibility of their compositeness is related to preons and the discussion why it's problematic would be similar to this one but it would differ in some important details. The conclusion is that composite gauge bosons are even more problematic than preons.)

Also, you won't be able to produce three families out of a "simpler list of preons". To produce exactly three families, you need something that comes in three flavors, i.e. a particle of "pure flavor" that has three subtypes and that binds to other particles to make them first- or second- or third-generation quarks or leptons. But there must still be other particles that carry the weak and strong charges so the result just can't be simpler.

The comments above were really way too optimistic. The actual problems with the "diversity of the bound states" that you get out of preons are much worse. Much like there are hundreds of hadron species, you typically predict hundreds of bound states of preons. Moreover, they should allow multiple arrangements of the preons' spins, they should be ready to be excited, and they should produce much more structured bound states. None of these things is observed and the predicted structure just doesn't seem to have anything to do with the observed, rather simple, list of quark and lepton species.

But there exists a problem with preons that is even more serious: their mass.

If it makes any sense to talk about them as new particles, they must have some intrinsic rest mass, much like quarks and leptons. What can the mass be? We may divide the possibilities to two groups. The masses may either be smaller than \(1\TeV\) or greater than \(1\TeV\). I chose this energy because it's the energy that is slightly smaller than the LHC beams and that is already "pretty nicely accessible" by the LHC collider. Maybe I should have said \(100\GeV\) but let's not be too picky.

If the new hypothetical preons are lighter than \(1\TeV\), then the new hypothetical particles are so light that the LHC collider must be producing them rather routinely. If that were so, they would add extra bumps and resonances and corrections and dilution to various charts coming from the LHC. Those graphs would be incompatible with the Standard Model that assumes that there are no preons, of course. But it's not happening. The Standard Model works even though it shouldn't work if the preons were real and light.

So we're left with the other possibility, namely that preons are heavier than \(1\TeV\) or \(100\GeV\) or whatever energy similar to the cutting-edge energies probed by the LHC these days. But that's even worse because the very purpose of preons is to explain quarks and leptons as bound states of preons ? and the known quarks and leptons are much lighter than \(1\TeV\).

To get a \(100\MeV\) strange quark, to pick a random "mediocre mass" example, the rest mass of preon(s) inside the quark, several \(\TeV\), would have to be almost precisely cancelled by other contributions to the mass and energy, with the accuracy better than 1 in 10,000. Clearly, the extra terms can't be kinetic energy which is positively definite: the compensating terms would have to be types of negative (binding) potential energy.

But it's extremely unlikely for the energy to be canceled this accurately, especially if you expect that the cancellation holds for many different bound states of preons (because many quarks and leptons are light).

Note that the virial theorem tells us that in non-relativistic physics, it's normal that the kinetic energy and the potential energy are of the same order. For example, for the harmonic oscillator with the \(kx^2/2\) potential energy, the average kinetic energy and the average potential energy are the same. For the Kepler/Coulomb problem, \(V\sim - k/r\), and the kinetic energy is \((-1/2)\) times the (negative) potential energy. More generally,\[

2\langle E_{\rm kin}\rangle = -\sum_{m=1}^N \langle \vec F_m\cdot \vec r_m\rangle

\] and if the potential goes like \(V\sim k r^n\), then \[

\langle E_{\rm kin} \rangle =\frac{n}{2} \langle V\rangle.

\] If you need the potential energy to cancel, you have to assume \(n=-2\). But the attractive potentials \(-1/r^2\) are extremely unnatural in 3+1 dimensions where \(-1/r\) is the only natural solution to the Poisson-like equations you typically derive from quantum field theories. You won't be able to derive them from any meaningful theory. Moreover, relativistic corrections will destroy the agreement even if you reached one. I was assuming that the motion of preons may be represented by non-relativistic physics ? because the preons are pretty heavy and at relativistic speeds, they would be superheavy. If you assume that they're heavy and relativistic (near the speed of light), you will face an even tougher task to compensate their relativistically enhanced kinetic energy.

Even if you fine-tuned some parameters to get a cancellation, it will probably not work for other preon bound states. The degree of fine-tuning needed to obtain many light bound states is probably amazingly high. And we're just imposing a few conditions ? the existence of light bound states that may be called "leptons and quarks". We should also impose all other known conditions ? e.g. the non-existence of all the other bound states that the preon model could predict and the right interactions of the bound states with each other and with other particles ? and if we do so, we find out that our problems are worse than just a huge amount of fine-tuning. We simply won't find any working model at all even if we're eager to insert arbitrarily fine-tuned parameters.

If you think about the arguments above, you are essentially learning that you shouldn't even attempt to explain light elementary particles ? those that are lighter than the energy frontier, e.g. the energy scale that is being probed by the current collider ? as composites. It can never really work. Quarks and leptons are much lighter than the LHC beam energy and because no sign of compositeness (involving new point-like particles) has been found, it really means that there can't be any.

Compositeness has done everything for us

So while the idea of compositeness is responsible for many advances in the history of physics, nothing guarantees that such "easy steps" may be done indefinitely. In fact, it seems likely that there won't be another step of this sort although some bold proposals that the top quark etc. could still be composite exist and are marginally compatible with the known facts.

After all, wouldn't you find it painful if the progress in physics were reduced to repeating the same step "our particles are composed of even smaller ones" that you would repeatedly and increasingly more mechanically apply to the current list of particles? The creativity in physics would be evaporating.

There exists a sense in which quarks and leptons are composite and the counter-arguments above are circumvented. In string theory, a lepton or a quark is a string. That means that you may interpret each such elementary particle as a bound state of "many string bits", pearls or beads along the string. If the number of conjectured "smaller building blocks" becomes infinite, like it is in the case of the stringy shape of an elementary particle, the cancellation between the kinetic and potential energy may become totally natural.

Despite the inner structure of elementary particles, string theory has an explanation why there are massless (or approximately massless, in various approximations) particles in the stringy spectrum. To some extent, this masslessness is guaranteed by having the "critical spacetime dimension" \(D=10\) or \(D=26\) for the superstring and bosonic string case, respectively. Well, string theory circumvents another problem we mentioned, too. We said that the kinetic energy is positive and the sum of all such positive terms must be positive, too. However, string theory uses the important fact that the sum of all positive integers equals \(-1/12\) which provides us with a very natural opportunity to cancel infinitely many terms although all of them seem to be positive.

Comparing preons and superpartners

The LHC hasn't found traces of any new particles beyond those postulated by the Standard Model of particle physics yet. However, that doesn't mean that all proposals for new physics are in the same trouble. In particular, I think it's important to explicitly compare preons with superpartners predicted by the supersymmetry.

At some point in the discussion above, I mentioned that preons could be either lighter or heavier than \(1\TeV\). The case of "light new particles" is generally excluded by the LHC (and previous experiments) because we would have already produced these new particles if they existed and if they were light.

The case of preons heavier than \(1\TeV\) was problematic because their "already high mass" must have been accurately cancelled by some negative contributions to the total energy/mass of the bound states and the negative potential energy required to do so seemed impossible, fine-tuned, and generally hopeless.

But the case of superpartners heavier than \(1\TeV\) doesn't have any problems of this sort. No supersymmetry phenomenologist really has any "rock solid" argument of this sort that would imply that the gluino is lighter than \(1\TeV\) or heavier than \(1\TeV\). We just don't know, these new particles may be discovered at every moment, and even at several \(\TeV\) or so, they still immensely improve the situation with the fine-tuning of the Higgs mass etc.

So while preons are pretty much completely dead ? because you just can't construct light particles out of heavy ones, if I oversimplify just a tiny bit ? superpartners remain immensely viable and well-motivated. The superpartners may still be rather light ? the lower bound on their mass are often significantly lower than the lower bounds on other particles' masses in models of new physics ? but there's nothing wrong about their being much heavier, either.

Much like in many texts, it's important not to become a dogmatic advocate of some ideas you decide to "love" in the first five minutes of your research. You could fall in love with the preons. Except that if you impartially study them in much more detail, you find out that this paradigm doesn't really agree with the known features of the world of particles well and some clever enough arguments may actually exclude rather vast and almost universal classes of such models. You should never become a blinded advocate of a theory who becomes blind to arguments of a certain type, e.g. the negative ones that unmask a general disease of your pet theory.

Preons are pretty much hopeless while other models of new physics remain extremely well motivated and promising.

And that's the memo.

Czechia celebrates the main national holiday today, the anniversary of the 1918 birth of Czechoslovakia.

Source: http://motls.blogspot.com/2012/10/preons-probably-cant-exist.html

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Navy replaces admiral leading Mideast strike group

WASHINGTON (AP) ? The U.S. Navy said Saturday it is replacing the admiral in command of an aircraft carrier strike group in the Middle East, pending the outcome of an internal investigation into undisclosed allegations of inappropriate judgment.

Rear Adm. Charles M. Gaouette is being sent back to the USS John C. Stennis' home port at Bremerton, Washington stae, in what the Navy called a temporary reassignment. The Navy said he is not formally relieved of his command of the Stennis strike group but will be replaced by Rear Adm. Troy M. Shoemaker, who will assume command until the investigation is completed.

It is highly unusual for the Navy to replace a carrier strike group commander during its deployment.

The Navy did not reveal details of the allegations, citing only an accusation of "inappropriate leadership judgment" that arose during the strike group's deployment to the Middle East. Rear Adm. John Kirby, the Navy's chief spokesman, declined to discuss the investigation.

The Stennis group deployed from Bremerton in late August and had entered the Navy 5th Fleet's area of operations in the Middle East on Oct. 17 after sailing across the Pacific. The Stennis made port visits in Thailand and Malaysia on its way to the Middle East.

It deployed four months earlier than scheduled in response to a request by the commander of U.S. Central Command, Marine Gen. James Mattis, to maintain two aircraft carriers in the Middle East. The Stennis replaced the USS Enterprise carrier group.

Defense Secretary Leon Panetta visited the Stennis and its sailors in Bremerton shortly before they departed. He thanked them for accelerating their deployment on short notice.

"I understand that it is tough," Panetta said. "We are asking an awful lot of each of you, but frankly you are the best I have and when the world calls we have to respond."

Source: http://news.yahoo.com/navy-replaces-admiral-leading-mideast-strike-group-135537654.html

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Sunday, October 28, 2012

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Source: http://today.msnbc.msn.com/id/7358550/ns/today-entertainment/

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Novel genes that may drive rare, aggressive form of uterine cancer identified

ScienceDaily (Oct. 28, 2012) ? Researchers have identified several genes that are linked to one of the most lethal forms of uterine cancer, serous endometrial cancer. The researchers describe how three of the genes found in the study are frequently altered in the disease, suggesting that the genes drive the development of tumors. The findings appear in the Oct. 28, 2012, advance online issue of Nature Genetics. The team was led by researchers from the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health.

Cancer of the uterine lining, or endometrium, is the most commonly diagnosed gynecological malignancy in the United States. Also called endometrial cancer, it is diagnosed in about 47,000 American women and leads to about 8,000 deaths each year.

Each of its three major subtypes -- endometrioid, serous and clear-cell -- is caused by a different constellation of genetic alterations and has a different prognosis. Endometrioid tumors make up about 80 percent of diagnosed tumors. Surgery often is a complete cure for women with the endometrioid subtype, since doctors usually diagnose these cases at an early stage.

Compared to other subtypes, the 2 to 10 percent of uterine cancers that comprise the serous subtype do not respond well to therapies. The five-year survival rate for serous endometrial cancer is 45 percent, compared to 65 percent for clear-cell and 91 percent for endometrioid subtypes. Serous and clear-cell endometrial tumor subtypes are clinically aggressive and quickly advance beyond the uterus.

"Serous endometrial tumors can account for as much as 39 percent of deaths from endometrial cancer," said Daphne W. Bell, Ph.D., an NHGRI investigator and the paper's senior author. Dr. Bell heads the Reproductive Cancer Genetics Section of NHGRI's Cancer Genetics Branch.

To determine which genes are altered in serous endometrial cancer, Dr. Bell and her team undertook a comprehensive genomic study of tumors by sequencing their exomes, the critical 1 to 2 percent of the genome that codes for proteins.

"Exome sequencing is a powerful tool for revealing important insights about this form of cancer that exacts such a high toll for thousands of women," said NHGRI Scientific Director Dan Kastner, M.D., Ph.D. "This study pinpoints genetic alterations that may be essential for onset and progression of uterine cancers and may eventually lead to new therapeutic targets."

Dr. Bell's team focused on the rarer, more aggressive forms of endometrial cancer. They began their study by examining serous tumor tissue and matched normal tissue from 13 patients. National Cancer Institute and Massachusetts General Hospital pathologists processed the 26 tissue samples, which subsequently underwent whole-exome sequencing at the NIH Intramural Sequencing Center.

With the exome data in hand, the researchers filtered through millions of data points to locate alterations, or mutations. They disqualified from the analysis any mutation found in a tumor and its matched healthy tissue, looking expressly for mutations that occurred exclusively in the tumor cells. They also eliminated one of the 13 tumors from analysis because its exome had hundreds more unique mutations than any other tumor.

The researchers detected more than 500 somatic mutations within the remaining 12 tumors. They next looked for genes that were mutated in more than one of the tumors. An alteration that occurs in more than one tumor is more likely to be relevant to the development of the cancer than a unique alteration.

"When you identify a set of mutations, they could either be drivers that have caused the cancer or incidental passengers that are of no consequence; our goal is to identify the drivers," Dr. Bell explained. "One way to do this is to home in on genes that are mutated in more than one tumor, because we know from experience that frequently mutated genes are often driver genes."

The team felt confident that alterations in nine genes could be driver genes in serous endometrial cancer. Three of the nine genes had previously been recognized by researchers in the cancer genetics field as a cause of serous endometrial cancer. To get a clearer picture of driver gene status among the other six genes, the researchers sequenced each gene in 40 additional serous endometrial tumors. They discovered that three of the six genes -- CHD4, FBXW7 and SPOP -- are altered at a statistically high frequency in serous endometrial cancer.

The team also found that this set of three genes is mutated in 40 percent of the serous endometrial cancer tumors and in 15 to 26 percent of the other endometrial cancer subtypes.

Probing still further, the researchers looked for the same genes highlighted by their exome sequencing study within databases that organize genes according to their biological function. They found an enrichment of genes involved in chromatin remodeling, the dynamic process by which the contents of the cell nucleus, including DNA, are packaged and modified. Chromatin remodeling enables tightly packaged DNA to be accessed for the expression of genes. Intriguingly, CHD4 was one of the genes that formed the chromatin-remodeling cluster.

"We sequenced the other genes that make up this cluster and, as a set, these genes are frequently mutated in both serous and clear-cell endometrial tumors," said Dr. Bell.

They also noted frequent mutations in genes that regulate a process known as ubiquitin-mediated protein degradation. The process targets unneeded proteins for destruction, and thus prevents them from accumulating within the cell. Left to accumulate, some of the target proteins are known to drive cancer formation. FBXW7 and SPOP are both known to play a role in binding to the unneeded proteins and targeting them for destruction.

Many of the FBXW7 gene mutations that Dr. Bell's team identified are known in other cancers to be driver mutations that prevent the FBXW7 protein from binding to its target protein. Dr. Bell believes that altered SPOP may behave the same way. "All the mutations we found in SPOP are in the region that binds the target proteins" she said. "We suspect the mutations in SPOP might lead to the accumulation of the unneeded proteins within the cell. But that has to be tested."

The current findings build on the team's 2011 study that showed for the first time that alterations in the PIK3R1 gene occur in all subtypes of endometrial cancer and are most frequent in the more common endometrioid subtype.

"This discovery really changes our understanding of some of the genetic alterations that may contribute to this disease," Dr. Bell said, acknowledging that the findings are limited by the small number of tumors subjected to exome sequencing.

She noted that it is too early to make a direct connection between their findings and prospects for treatments for this aggressive form of uterine cancer.

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The above story is reprinted from materials provided by NIH/National Human Genome Research Institute, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Matthieu Le Gallo, Andrea J O'Hara, Meghan L Rudd, Mary Ellen Urick, Nancy F Hansen, Nigel J O'Neil, Jessica C Price, Suiyuan Zhang, Bryant M England, Andrew K Godwin, Dennis C Sgroi, NIH Intramural Sequencing Center (NISC) Comparative Sequencing Program, Philip Hieter, James C Mullikin, Maria J Merino & Daphne W Bell. Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes. Nature Genetics, 28 October 2012 DOI: 10.1038/ng.2455

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/ABJ_acotIR8/121028142312.htm

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